Analysis of Diagnosis Value on S Index Evaluating Slight Chronic Hepatitis B Fibrosis
10.16466/j.issn1005-5509.2015.03.010
- VernacularTitle:S指数评价轻型慢乙肝肝纤维化程度的诊断价值分析
- Author:
Shiya SONG
;
Xiaohong ZHU
- Publication Type:Journal Article
- Keywords:
CHB;
liver fibrosis;
noninvasive diagnosis model;
liver tissue pathology;
S index;
receiver operating characteristic curve
- From:
Journal of Zhejiang Chinese Medical University
2015;(3):199-201
- CountryChina
- Language:Chinese
-
Abstract:
Objective] To observe the diagnosis value of noninvasive diagnosis model S index used to evaluate the fibrosis degree of slight chronic hepatitis B(CHB). [Method] Trace back and investigate the routine serological indicators GGT, PLT, ALB and liver aspiration biopsy results of 63 cases of CHB;use noninvasive diagnosis formula to calculate:S index=1000×GGT/(PLT×ALB2),use ROC curve to analyze and evaluate the clinical diagnosis value of S index. [Result] S index is in positive relation with liver fibrosis degree. S index can forecast the fibrosis having or not with best truncation point 0.04h, the sensitivity 87.0%, specificity 47.5%and area under the curve(AUC) 0.690,close to 0. 7; in forecasting obvious fibrosis, with best truncation point 0.04h, sensitivity 100%,specificity 36.8%,AUC 0.664. [Conclusion] S index used for forecasting slight CHB having or not fibrosis has high value of diagnosis, but it has low correctness for diagnosing having or not obvious liver fibrosis.