The effective of FGF-23(R176Q)overexpress in adult mouse mandible formation and mineralization

VernacularTitle:FGF-23（R176Q）过表达对成年小鼠下颌骨形成和矿化的影响
Author: Hong LIU ; Wen SUN ; Yangyu ZHENG
Publication Type:Journal Article
Keywords: FGF-23; overexpression; mineralization; bone matrix
From: Chongqing Medicine 2015;(7):888-890
CountryChina
Language:Chinese
Abstract: Objective To investigate the effective of FGF-23(R176Q)overexpression of adult mouse mandible formation and mineralization.Methods CT scanning,serological examination,HE staining,immunohistochemical staining and RT-PCR analysis were used to compared mandible of FGF-23(R176Q)transgenic mice(TG group)and wild type mice(WT group),serum calcium and phosphorus concentrations mandibule formation and mineralization were analysised.Results Serum calcium,phosphorus and 1, 25(OH)2 D3 concentrations in WT group were significantly higher than that in TG group,the difference was statistically significant (P <0.05);the Ob.s/B.Pm TG group was lower than that of WT group,the difference was statistically significant(P <0.05);the positive percentage of Biglycan in TG group was higher than that in WT group,the difference was statistically significant(P <0.05);the OCN and type I collagen mRNA levels in the WT group were significantly higher than that in TG group,the difference were statistically significant(P <0.05).Conclusion FGF-23(R176Q)overexpression can inhibit the formation of mandible,reduce the formation of mineralized,and reduce the development of the mandible.