Clinical significance and the expression of NT-proBNP and copeptin in patients with acute cerebral hemorrhage
10.3969/j.issn.1671-8348.2015.07.016
- VernacularTitle:急性脑出血患者血浆N端脑钠肽前体、和肽素的检测及其临床意义
- Author:
Yongkai YANG
;
Fan ZHANG
;
Shaohua XUE
;
Xiangzhong HE
;
Wei GAO
;
Dun LIU
;
Xiaohui ZHOU
- Publication Type:Journal Article
- Keywords:
acute cerebral hemorrhage;
amino-terminal pro-brain natriuretic pepfide(NT-proBNP);
copeptin;
glasgow coma scale(GCS);
hematoma volumes
- From:
Chongqing Medicine
2015;(7):910-912
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship of plasma concentration of NT-proBNP,copeptin and glasgow coma scale(GCS)scores,hematoma volumes in patients with acute cerebral hemorrhage.Methods 109 patients with acute cerebral hem-orrhage(the cerebral hemorrhage group)and 32 healthy individuals (the control group)admitted in our hospital from December 2011 to June 2013 were selected and detected for plasma NT-proBNP and copeptin.The levels of NT-proBNP,copeptin,glasgow co-ma scale(GCS)scores and hematoma volumes were compared between the two groups.Results The levels of plasma NT-proBNP and copeptin in the cerebral hemorrhage group were significantly higher than that in control group(P <0.05).The levels of plasma NT-proBNP and copeptin were significantly increased with the severity and the hematoma volume of the acute cerebral hemorrhage. The levels of NT-proBNP and copeptin are positively correlated with hematoma volumes(r=0.63,r=0.58,P <0.01)and negative-ly correlated with Glasgow Coma Scale(GCS)scores(r=-0.52,r=-0.46,P <0.01).Conclusion The levels of NT-proBNP and copeptin are positively correlated with hematoma volumes and negatively correlated with glasgow coma scale(GCS)scores.They are important clinical parameters to reflect the severity and hematoma volumes of the acute cerebral hemorrhage.
