Transition from endocapillary proliferative glomerulonephritis to membrane proliferative glomerulonephritis：a case report
10.3969/j.issn.1000-3606.2015.03.012
- VernacularTitle:毛细血管内增生性肾炎转变为膜增生性肾炎1例报告
- Author:
Hongbo ZHANG
;
Jianping HUANG
- Publication Type:Journal Article
- Keywords:
acute poststreptococcal glomerulonephritis;
endocapillary proliferative glomerulonephritis;
membraneproliferative glomerulonephritis;
complement C3
- From:
Journal of Clinical Pediatrics
2015;(3):247-250
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the mechanism, diagnosis and treatment of membrane proliferative glome-rulo-nephritis (MPGN) transitioned from endocapillary proliferative glomerulonephritis (EnPGN).Methods The clinical data and the results of pathological examination of one case of MPGN transitioned from EnPGN were retrospectively analyzed.Results The child was presented with proteinuria, microscopic hematuria, and persistent low level of complement C3. The type of renal pathology was transitioned from EnPGN to MPGN. Complete remission was achieved in this child with the treatment of oral prednisolone and tacrolimus, but the level of plasma complement C3 remained low.Conclusions The type of renal pathology in children with persistent low level of complement C3 could make a transition, and the early diagnosis, timely and effective treat-ment are important.
