A relevant study of MSCT sign and expression of HER2 in gastric cancer
10.3969/j.issn.1002-1671.2015.03.021
- VernacularTitle:胃癌 MSCT表现与HER2基因表达情况的相关性研究
- Author:
Songwei YUE
- Publication Type:Journal Article
- Keywords:
gastric cancer;
HER2;
computed tomography
- From:
Journal of Practical Radiology
2015;(3):427-430
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation between the MSCT sign of gastric cancer and the expression of human epidermal growth factor receptor 2 (HER2)gene in the cancer tissues.Methods 105 cases of gastric cancer diagnosed by pathology after sur-gery underwent MSCT before surgery,then the correlation was analyzed between MSCT shows and the expression of HER2 gene detected by immunohistochemistry after surgery by the statistical method.Results The age,sex,site of tumor,stage and CT value of plain scan were not correlated with the expression of HER2 (P>0.05).Compared to the group without HER2 expression,CT value in venous phase,the enhancement degree in both arterial and venous phase and the incidence of enlarged lymph nodes around the stomach were higher in HER2 positive expression group,the differences were significant (P<0.05),while CT value in arterial phase were not significantly different (P>0.05).Compared to the HER2 (0&1+)group,CT value,the enhancement agree in venous phase and the incidence of enlarged lymph nodes around the stomach were higher,in HER2 (2+&3+)group,the differences were significant (P<0.05),while CT value and the enhancement in arterial phase were not significantly different (P>0.05).Conclusion There are different signs in MSCT with different expression of HER2 in gastric cancer,the combinations of them can evaluate the prognosis of gastric cancer.
