Evaluation of TAZ and KLF5 expression and their clinical significance in hepato-cellular carcinoma
10.3969/j.issn.1000-484X.2015.03.019
- VernacularTitle:TAZ和KLF5在肝细胞癌组织中的表达及其临床意义
- Author:
Junren CHEN
;
Dinghua YANG
;
Yanhua SUN
;
Qing HAN
;
Minjie ZHANG
- Publication Type:Journal Article
- Keywords:
TAZ;
KLF5;
Hepatocellular carcinoma;
Tumor progression
- From:
Chinese Journal of Immunology
2015;(3):380-383
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expression of TAZ and KLF5 and their clinical significance in hepatocellular carcinoma ( HCC).Methods:We freshly collected 76 samples of surgically resected HCC and matched normal tumor-adjacent tissues and detected TAZ and KLF5 expression in these samples using immunohistochemical staining.The clinical significance of TAZ and KLF5 protein expression were analysed.Results:The protein expression of TAZ and KLF5 in HCC tissues was significantly higher than those in matched normal tumor-adjacent tissues ( P=0.001;P=0.035 ).Clinicopathological analysis suggested that TAZ and KLF5 protein expression were associated with histopathological differentiation ( P=0.007;P=0.047 ) and TNM stage ( P=0.009;P=0.040).TAZ was positively correlated with KLF5 protein in HCC tissues (r=0.651,P=0.003).Conclusion:The high-expression of TAZ and KLF5 are correlated with poor clinicopathological characteristics,and TAZ is positively associated with KLF5 in HCC tissues, suggesting that TAZ may promote tumor progression through inhibition of KLF5 protein degradation in HCC.
