Study on Preparation Technology of Repaglinide and Metformin Hydrochloride Tablets
- VernacularTitle:瑞格列奈二甲双胍片制备工艺研究
- Author:
Yang XIN
;
Long YONG
;
Lin LI
- Publication Type:Journal Article
- Keywords:
Repaglinide;
Metformin;
Accumulative dissolution;
Dissolution curve;
Similarity factor
- From:
China Pharmacist
2015;(3):493-496
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To design and prepare repaglinide and metformin hydrochloride tablets for pilot scale test and industrial pro-duction. Methods:Dissolution was applied to optimize the formula and preparation process. Results: The tablets were prepared ac-cording to the determined formula and process with poloxamer 188, meglumine, PVP K30, croscarmellose sodium, microcrystalline cellulose PH101, sorbitol, magnesium stearate and coating powder as the adjuvants. The dissolution behavior of the tablets in four media was similar to that of the reference. Conclusion:The preparation process of repaglinide and metformin hydrochloride tablets is simple and feasible, and the quality is controllable and stable.
