Effect of rosuvastatin and memantine on endothelial progenitor cells in vascular dementia rats
10.3969/j.issn.1009-0126.2015.03.021
- VernacularTitle:瑞舒伐他汀和美金刚对血管性痴呆大鼠内皮祖细胞的影响
- Author:
Chenchen SONG
;
Nan ZHANG
;
Yan CHENG
- Publication Type:Journal Article
- Keywords:
dementia,vascular;
memantine;
stem cells;
memory disorders;
endothelial cells
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2015;(3):299-302
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of rosuvastatin and memantine on EPC and learning or memory ability in VaD rats .Methods Forty adult male SD rats were randomly divided into sham operation group ,VaD model group ,memantine treatment group ,rosuvastatin treatment group , and memantine+rosuvastatin treatment group (combined treatment group) (8 in each group) .A VaD model was established by permanent ligation of bilateral common carotid arteries .The ani‐mals in rosuvastatin treatment group ,memantine treatment group and combined treatment group received gastric rosuvastatin 10 mg/(kg · d) ,memantine 10 mg/(kg · d) and memantine 10 mg/(kg · d)+rosuvastatin 10 mg/(kg · d) for 4 weeks while those in model group received gastric normal saline .Five weeks after operation ,the learning or memory ability was tested by Morris water maze test ,the escape latency and percentage of target quadrant were calculated ,the circulat‐ing EPC were detected by flow cytometry ,and the MVD in hippocampaus was assyed with vWF immunostaining .Results Five weeks after operation ,the learning or memory ability was signifi‐cantly lower in model group than in sham operation group (P< 0 .01) whereas the learning or memory ability ,the percentage of circulating EPC and the MVD in hippocampus were significantly higher in 3 treatment groups than in model group (P<0 .05) .Conclusion Rosuvastatin and me‐mantine can effectively improve the learning or memory ability of VaD rats by mobilizing their cir‐culating EPC and increasing the MVD in their hippocampus .However ,the effect of memantine or rosuvastatin does not differ greatly w hen they are used alone .
