Changes and significance of CD4+CD25+regulatory T cells and cytokines in patients with rheumatic heart disease
10.3969/j.issn.1000-484X.2014.03.021
- VernacularTitle:风湿性心脏病患者的 CD4＋CD25＋调节性 T细胞及细胞因子的改变及意义
- Author:
Liankai WANG
- Publication Type:Journal Article
- Keywords:
Rheumatic heart disease;
CD4+CD25+regulatory T cells;
Cytokines
- From:
Chinese Journal of Immunology
2015;(3):389-392
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To discuss the changes and significance of CD4+CD25+regulatory T cells and cytokines in patients with rheumatic heart disease compared to the normal people.Methods:Clinical data of patients with RHD received treatment at our hospital from April 2012 to July 2010 was retrospectively analyzed.The normal control group was the healthy physical examination persons form the medical examination center at our hospital.The expression levels of growth factorβ1 (TGF-β1),tumor necrosis factor alpha (TNF-α),interleukin-10 (IL-10),interleukin-6 (IL-6) and CD4+CD25+regulatory T cells in the peripheral blood samples of the objects in the two groups were detected and compared.Results:A total of 76 patients were retrospective analyzed,including 40 in observe group and 60 in control group.The percent of CD4+CD25+T accounted for lymphocyte and the percent of CD4+CD25+Foxp3+Treg accounted for CD4+T in observe group were obviously lower than those in control group.The TGF-β1 and IL-10 in observe group were obviously lower than those in control group.The TNF-αand IL-6 in observe group were obviously higher than those in control group.The differences had statistical significance.Conclusion: The CD4+CD25+ regulatory T cells in patients with RHD were obviously decreased.The blood cytokines such as TGF-β1 and IL-10 were corresponding declined.
