Detective value of autoimmune antibodies in autoimmune diseases
10.3969/j.issn.1000-484X.2015.03.024
- VernacularTitle:自身抗体检测在自身免疫性疾病中的价值
- Author:
Shifeng QIN
;
Chunmei LI
- Publication Type:Journal Article
- Keywords:
Autoimmune disease;
Autoantibody;
Correlation
- From:
Chinese Journal of Immunology
2015;(3):401-403
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the sensitivity and correlation between ANA,ENA and anti ds-DNA antibody in the patients with AID.Methods:Clinical data of patients with AID received treatment at our hospital from February 2013 to January 2014 was retro-spectively analyzed.The antibody expressions of ENA, ANA, anti ds-DNA antibody of the patients were detected.The autoantibody positive differences between the males and females were compared.The positive situation of ENA correspond to different fluorescent patterns of ANA and the correlation between the expression of ANA and the expressions of ENA,anti ds-DNA antibody were both dis-cussed.The relationship between the expression of ANA and the expression of ENA,dsDNA was also discussed.Results:A total of 180 patients were retrospective analyzed,including 67 males and 113 females.The positive rates of ANA,anti ds-DNA antibody in females were obviously higher than those in males.The rate of particle type ANA in the positive specimens of nRNP,ss-A was the highest.The rate of homogeneous type ANA of the positive specimens of Scl-70 was the highest.The granular pattern of the positive specimens of nRNP,ss-A had the highest rate in ANA.The homogeneous pattern of the positive specimens of Scl-70 had the highest rate in ANA.The positive rates of ENA, anti ds-DNA antibody in the positive specimens of ANA were obviously higher than those in the negative specimens of ANA.Conclusion:The positive rate of autoantibody in males was obviously lower than that in females.The particle type occupied higher rate in the karyotype of ANA.There was relationship between the positive detection rate of anti ds-DNA antibody,ENA and the positive rate of ANA.
