Comparison of Drug Release in vitro of Diclofenac Sodium Sustained-release Capsules and Sustained-release Tablets from Different Manufacturers
- VernacularTitle:不同厂家双氯芬酸钠缓释胶囊与缓释片的体外释放度比较
- Author:
He JIAN
;
Zhang YAN
- Publication Type:Journal Article
- Keywords:
Diclofenac sodium;
Dissolution;
HPLC;
Weibull equation
- From:
China Pharmacist
2015;(3):523-525
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To establish an HPLC method for the determination of diclofenac sodium sustained-release preparations, and compare the in vitro dissolution of diclofenac sodium sustained-release capsules and tablets from different manufacturers to provide reference for the clinical reasonable medication. Methods: According to the first dissolution method described in Chinese Pharmaco-poeia (2010 edition),the dissolution of each sample was determined by HPLC and the cumulative release percentage was calculated. The dissolution parameters were fitted by Weibull-equation and the results were analyzed. Results:The HPLC method for the determi-nation of diclofenac sodium release was accurate with good reproducibility, and the dissolution parameters of different manufacturers had remarkable difference. Conclusion:The in vitro dissolution of diclofenac sodium sustained-release capsules and tablets from different manufacturers is various, which should be paid attention in the clinical use.
