Effect of long-acting nitrate on expression of Ang Ⅱ receptor subtypes in kidneys of heart failure rats
10.3969/j.issn.1009-0126.2015.03.020
- VernacularTitle:长效硝酸酯对心力衰竭大鼠肾脏血管紧张素Ⅱ受体表达水平的影响
- Author:
Yubo PENG
;
Yangfang LI
;
Mengmeng CHEN
- Publication Type:Journal Article
- Keywords:
receptor,angiotensin,type 2;
myocardial infarction;
heart failure;
cardiovascular agents
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2015;(3):295-298
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of long‐acting nitrate on cardiac function and expression of AngⅡreceptor (ATR)subtypes in kidneys of chronic heart failure (CHF)rats after myocardial infarction .Methods Ninety male Wistar rats aged 10 weeks were randomly divided into control group (group A ,n=9) ,sham operation group (group B ,n=8) ,HF model group (group C ,n=9) , low Elantan dose group (group D ,n=9) ,high Elantan dose group (group E ,n=9) ,olmesartan group (group F ,n=9) ,and combined high Elantan dose and olmesartan group (group G ,n=8) .A HF model was established by ligating the left anterior descending artery .The animals received gastric drugs for 6 weeks .Their cardiac function was assyed by ultrasound echocardiography and expressions of AT1 R and AT2 R were detected by RT‐PCR and Western blot ,respectively .Results The PRA and AngⅡexpression levels were significantly higher ,the AT1 R expression level was significantly higher and the AT2 R expression level was significantly lower in group C than in group B (P<0 .01 ,P<0 .05) .The PRA and AngⅡexpression levels were significantly lower ,the AT1 R expression level was significantly lower and the AT2 R expression level was significantly higher in groups E‐G than in group C (P<0 .05 ,P<0 .01) .The receptor expression levels were much higher in group G than in group F (P<0 .05) .Conclusion Long‐term use of long‐acting nitrate can effectively improve cardiac function and protect renal function .
