Effect of memantine on N-methyl-daspartate receptor in vascular dementia rats
10.3969/j.issn.1009-0126.2015.03.022
- VernacularTitle:盐酸美金刚对血管性痴呆大鼠 N-甲基-D天冬氨酸受体的影响
- Author:
Baomin ZHAO
;
Nan ZHANG
;
Yan CHENG
- Publication Type:Journal Article
- Keywords:
memantine;
dementia,vascular;
memory disorders;
receptors,N-methyl-D-aspartate
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2015;(3):303-306
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of memantine on NR1 ,NR2A ,NR2B of N‐methyl‐das‐partate receptor and learning or memory ability in vascular dementia (VaD) rats .Methods Thirty adult male SD rats were randomly divided into sham operation group ,VaD model group and me‐mantine treatment group (10 in each group) .A rat VaD model was established by permanent liga‐tion of bilateral common carotid arteries .Rats in memantine treatment group received gastric me‐mantine 10 mg/(kg · d) 1 week after operation while those in model group received normal sa‐line .Five weeks after operation ,their learning or memory ability was tested by Morris water maze test ,expressions of NR1 ,NR2A and NR2B were detected by Western blot .Results The escape latency was significantly longer whereas the percentage of target quadrant and expression levels of NR1 ,NR2A and NR2B were significantly lower in model group than in sham operation group (P=0 .001 ,P=0 .002 ,P<0 .05) .The learning or memory ability and the expression levels of NR1 ,NR2A and NR2B were significantly higher in memantine treatment group than in model group but still lower in memantine treatment group than in sham operation group ( P< 0 .05) . Conclusion Memantine can improve the learning or memory ability of VaD rats by upregulating the expression of NR1 ,NR2A and NR2B in their hippocampus .
