Effect of atorvastatin pretreatment and ischemia preconditioning on I/R injury in rats

VernacularTitle:阿托伐他汀预处理和缺血预处理对大鼠脑缺血再灌注损伤的保护作用
Author: Zhenghu XU ; Jun WANG
Publication Type:Journal Article
Keywords: brain ischemia; reperfusion injury; ischemic preconditioning; antilipemic agents; platelet aggregation inhibitors
From:Chinese Journal of Geriatric Heart Brain and Vessel Diseases 2015;(3):310-312
CountryChina
Language:Chinese
Abstract: Objective To study the effect of atorvastatin pretreatment and ischemia preconditioning on I/R injury in rats .Methods Thirty‐two Wistar rats were randomly divided into sham opera‐tion group ,I/R injury group ,ischemia preconditioning group ,and atorvastatin treatment group (8 in each group) .A reversible focal I/R injury model of rats was established by Longa occlusion of middle cerebral artery .Cerebral tissue samples w ere taken ,cut into 3 μm‐thick sections w hich were stained with HE to observe the morphologic changes in frontal lobe ,parietal lobe and hipp‐ocampal CA1 .Results The karyopyknosis in frontal lobe and cytoplasm acid degeneration in hip‐pocampal CA1 were more significantly in I/R injury group than in sham operation group ,ischemia preconditioning group and atorvastatin treatment group (P<0 .01) .Conclusion ischemia precon‐ditioning and atorvastatin pretreatment can protect rats against I/R injury .