The clinical effects of traditional Chinese medicine on Kawasaki disease:a systematic review of randomized controlled trials and Meta analysis
10.3969/j.issn.1008-9691.2015.02.004
- VernacularTitle:中医中药治疗川崎病临床疗效的系统评价及Meta分析
- Author:
Qi WAN
;
Yuping DENG
;
Suqi YAN
;
Jianqiao TANG
;
Hong LI
;
Fang WANG
- Publication Type:Journal Article
- Keywords:
Tradition Chinese medicine;
Kawasaki disease;
Randomized controlled trials;
Systematic review
- From:
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
2015;26(2):124-127
- CountryChina
- Language:Chinese
-
Abstract:
Objective To systemically evaluate the clinical therapeutic effect and safety of traditional Chinese medicine on Kawasaki disease. Methods Through retrieval of the reports in PubMed, the Cochrane Library, China National Knowledge Internet (CNKI), VIP database, Wanfang database by computer, the correlative articles of clinically randomized controlled trials (RCTs) published in China during the period from 1990 to 2013 were collected, and their quality evaluation was made. All the articles were screened according to inclusion and exclusion criteria, in which interventions were traditional Chinese medicine therapy and conventional western treatment. The articles selected were assessed with the software of RevMan 5.2. Results There were 212 articles searched out, but only 13 articles, 656 children with Kawasaki disease were conformed to the inclusion criteria. The Meta analysis indicated that the total effective rate in the traditional Chinese medicine group was superior to the group treated with western medicine. The difference in the curative effects between the two groups had notable significance [odds ratio (OR) = 3.58, 95%confidence interval (95%CI) was 2.16-5.93, test for overall effect Z=4.94, P<0.000 01]. No difference was seen in the curative effect of improving coronary artery changes between the traditional Chinese medicine group and western medicine control group (OR=2.03, 95%CI was 0.74-5.62, test for overall effect Z=1.37, P=0.17). Conclusion The clinical therapeutic effect of traditional Chinese medicine on Kawasaki disease is superior to that treated by western medicine.
