Association between single nucleotide polymorphism in Nrf2 gene and acute mountain sickness

VernacularTitle:Nrf2基因单核苷酸多态性与急性高原病相关性研究
Author: Qianwen GENG ; Jihang ZHANG ; Jun QIN ; Lan HUANG ; Jun JIN
Publication Type:Journal Article
Keywords: acute mountain sickness; Nrf2 gene; polymorphism,single nucleotide
From: Military Medical Sciences 2015;(2):105-107
CountryChina
Language:Chinese
Abstract: Objective To explore the correlation of single nucleotide polymorphism ( SNP ) in Nrf2 gene with acute mountain sickness ( AMS) among Han populations in China .Methods As a nested case-control study , 603 Chinese Han young men who had been quickly exposed to 3700 m were adopted and divided into case group and control group ( 369 vs 234,respectively) by Lake Louise Self-assessment Scoring System(LLSS).The Sequenom Mass Array system was used to detect the SNPs of rs10497511 and rs2364722 in Nrf2 gene.Results Alleles of rs10497511 and rs2364722 were respec-tively detected in both case and control groups , which were T-C and A-G.Statistically significant difference was not found in allele frequencies ( P>0.05 ) .Further analysis showed that there was still no significant difference between the codomi -nant, dominant and recessive genotype models (P>0.05).Conclusion rs10497511 and rs2364722 of Nrf2 gene may not be related to susceptibility to AMS in Chinese Han populations .