Pathological features of pulmonary sclerosing hemangioma:an analysis of 120 cases in frozen section
10.13315/j.cnki.cjcep.2015.02.014
- VernacularTitle:肺硬化性血管瘤120例临床病理分析
- Author:
Jiafu LIU
;
Likun HOU
;
Chunyan WU
- Publication Type:Journal Article
- Keywords:
lung neoplasms;
pulmonary sclerosing hemangioma;
frozen diagnosis;
foam sample tissue cell and mast cells
- From:
Chinese Journal of Clinical and Experimental Pathology
2015;(2):174-177
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To analyze retrospectively the clinicopahological characteristics and immuophenotype in 120 cases of pulmonary selerosing hemangioma ( PSH) . Methods Data of 120 cases of PSH were collected and reviewed, including gross features and frozen diagnosis, histopathological features, morphology in HE and immunohistochemical characteristics of tumor cells. Results PSH pres-ents a well-circumscribed mass with a sense of expansion after cutting, which showed a solid, grey to tan-yellow surface with foci of haemorrhage. Two kinds of tumor cells and four typical patterns with mixed forms, are often shown under light microscope (92/120, 76. 67%). Focal accumulation of histocytes and scattered mast cells were noted in some cases (83/120, 69. 17%). Both surface cells and round cells were TTF-1 and EMA positive. Surface cells expressed SP-A, CK and NapsinA. Round cells expressed vimentin. Conclusion Gross features and typical“two cell types, four patterns” contribute to PSH diagnosis. Meanwhile, foal accumulation of foam histocytes and scattered mast cells show a clue to PSH diagnosis and differential diagnosis.
