Clinical significance of determination of serum neutrophil gelatinase associated lipocalin in the diagnosis of contrast induced nephropathy
10.3969/j.issn.1671-8348.2015.19.012
- VernacularTitle:血清中性粒细胞明胶酶相关脂质运载蛋白检测在造影剂肾病诊断中的临床意义
- Author:
Ji MA
;
Siyi LI
;
Lin CHEN
;
Chenyu SHANG
;
Yonghui DAI
;
Jianhua XU
- Publication Type:Journal Article
- Keywords:
neutrophil gelatinase associated lipocalin;
contrast induced nephropathy;
kidney injury
- From:
Chongqing Medicine
2015;(19):2626-2628
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the clinical significance of serum neutrophil gelatinase associated lipocalin(NGAL)detection in the diagnosis of contrast induced nephropathy .Methods A total of 299 inpatients with contrast medium in department of inten‐sive care unit(ICU) ,department of cardiovascular disease ,department of urology from Guangdong Province Hospital of Traditional Chinese Medicine were enrolled ,and the fasting blood glucose and lipids were detected .Sera were collected before examination of contrast medium and 1 ,2 and 6 d after examination of contrast medium respectively .Serum creatinine(SCr)and cystatin C(CysC) were detected ,the concentration of NGAL was determined .CIN was defined as of increased by 44 μmol/L or 25% from baseline in SCr within 24-48 h .The NGAL detection variation tendency was analyzed in different time point .Results In 299 cases ,CIN oc‐curred in 28 patients ,the incidence rate was 9 .36% .The diabetes patients in the incidence of CIN was 16 .21% (12/74) ,no inci‐dence of diabetic patients was 7 .11% (16/225) .When compared with that of before contrast ,CIN in serum of patients with Cr and CysC coronary angiography in 2 d significantly increased after contrast medium ,returned to the level before angiography on 6 d .But the serum NGAL in angiography 1 d after it was significantly increased (P<0 .05) ,statistically significant differences compared with pre contrast ,and was still at a high level on sixth day .Conclusion Prediction of CIN level of serum NGAL in contrast after 1 d could be a good predictor for CIN ,and the prediction time is earlier than the serum levels of Cr and CysC .The level of serum NGAL can be used for early diagnosis of CIN .
