ABRO1 and its research progress
10.7644/j.issn.1674-9960.2015.02.017
- VernacularTitle:ABRO1研究进展
- Author:
Jing XU
;
Xiaoming YANG
;
Jianhong ZHANG
- Publication Type:Journal Article
- Keywords:
ABRO1;
BRCC36;
BRISC-SHMT;
polyubiquitin chain
- From:
Military Medical Sciences
2015;(2):147-149
- CountryChina
- Language:Chinese
-
Abstract:
ABRO1 (Abraxas Brother 1), known also as KIAA0157 or FAM175B, is an important component of BRISC deubiquitinating enzyme ( DUB) complex which specifically shears K-63 linked polyubiquitin chains .This article reviews the research progress in ABRO 1 in terms of its structural characteristics , BRISC complex composition , the regulation of DUB activity and interferon response , oxidative stress response and anti-myocardial ischemia and provides new ideas on fur-ther study of the physiological function of ABRO 1 and its association with immune and cardiovascular diseases .
