Expression of podoplanin-positive stromal cells in esophageal squamous cell carcinoma and its clinical significance
10.13315/j.cnki.cjcep.2015.02.003
- VernacularTitle:食管鳞状细胞癌间质细胞中 podoplanin的表达及临床意义
- Author:
Xiaodong LIANG
;
Wenbin HUANG
;
Jinsong WANG
- Publication Type:Journal Article
- Keywords:
esophageal neoplasms;
squamous cell carcinoma;
podoplanin;
stromal cell
- From:
Chinese Journal of Clinical and Experimental Pathology
2015;(2):128-131
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To study the correlation between the expression of podoplanin-positive stromal cells and clinicopathologic features in squamous cell carcinoma ( SCC) of esophagus, and to explore the role of podoplanin-stromal cells in the progression of SCC of e-sophagus. Methods Immunohistochemical EnVision method was used to detect the expression of podoplanin in the stromal cells of e-sophageal SCC. The correlation between the expression of podoplanin-positive stromal cells and clinicopathologic features in SCC of e-sophagus was analyzed. Results Of 69 cases of SCC, podoplanin-positive stromal cells were seen in 43 and the positive rate was 62. 3%. Lymphatic vessel density in SCCs with podoplanin-positive stromal cell was 45. 72 ± 14. 36, which was higher than that with-out podoplanin-positive stromal cell (21. 23 ± 10. 49) (P<0. 01). Expression of podoplanin in stromal cells in SCCs with lymphatic vessel invasion was higher than those without lymphatic vessel invasion (P<0. 05). There was no correlation between podoplanin-posi-tive stromal cells and age, sex, tumor size, the depth of invasion, differentiation, lymph node metastasis, and clinical stage ( P>0. 05). Conclusion Podoplanin-positive stromal cells may promote the lymphangiogenesis and lymph vessel invasion of esophageal SCC.
