Expression of insulin-like growth factor-Ⅱ mRNA-binding protein 3 in preeclamptic placen-tas
10.13315/j.cnki.cjcep.2015.02.006
- VernacularTitle:子痫前期胎盘组织中IMP3的表达
- Author:
Hua ZHAO
;
Jie LIANG
;
Min ZHAO
;
Jianping XIAO
- Publication Type:Journal Article
- Keywords:
preeclampsia;
IMP3;
placenta;
immunohistochemistry
- From:
Chinese Journal of Clinical and Experimental Pathology
2015;(2):141-144
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To detect the expression of insulin-like growth factor-ⅡmRNA-binding protein 3 (IMP3) in preeclampsia (PE) placentas. Methods The levels of IMP3 expression were measured using immunohistochemistry in 8 cases of mild PE, 41 cases of se-vere PE, 6 cases of fetal growth restrict ( FGR) without PE and 22 cases of normal late trimester of pregnancy placentas. Results Compared with normal late trimester of pregnancy, the expression of IMP3 was obviously decreased in severe PE placenta ( Z =-2. 063,P<0. 05), decreased in mild PE (Z= -1. 31,P>0. 05). The expression of IMP3 in severe PE placenta was lower than that of mild PE placenta but not statistically significant (Z= -0. 233,P>0. 05). The expression of IMP3 in early onset PE placenta was lower than that of late onset PE placenta but not statistically significant(Z= -0. 108,P>0. 05). Compared with normal late tri-mester of pregnancy, the expression of IMP3 was significantly decreased in PE with FGR placenta (Z= -2. 375,P <0. 05), de-creased in FGR without PE and PE without FGR (Z= -1. 225,P>0. 05, Z= -1. 36,P>0. 05). Conclusion The results indicate that IMP3 protein expression is low in sever PE, which may be one of the pathogenesis of PE. IMP3 may be used as a marker to predict PE with FGR, and to provide a basis for the development of a novel therapeutic target in PE.
