Hepatoblastomas in childhood:a clinicopathologic analysis of 58 cases
10.13315/j.cnki.cjcep.2015.02.013
- VernacularTitle:小儿肝母细胞瘤58例临床病理分析
- Author:
Jing MA
;
Zhongde ZHANG
- Publication Type:Journal Article
- Keywords:
hepatoblastoma;
pathology;
clinical;
children;
diagnosis
- From:
Chinese Journal of Clinical and Experimental Pathology
2015;(2):169-173
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To study the morphological features, immunohistochemical phenotype, diagnosis and differential diagnosis of hep-atoblastoma in children. Methods The pathologic data of 58 child patients with hepatoblastoma were enrolled in this study, and histo-logical classification with distinct clinical associations were used. Prognostic data were also collected. Results Pure epithelial type was 33 cases, pure fetal type 18 cases, including 8 cases of low mitotic activity type, 9 cases of high mitotic activity, and 1 case of fo-cal pleomorphic type. 11 cases were embryonal type, 3 small undifferentiated type and 1 transitional liver cell tumor. All the 25 cases of mixed epithelial and mesenchymal type were without teratoid features, including fetal epithelial and mesenchymal type (6 cases), embryonal epithelial and mesenchymal type (17 cases), transitional liver cell tumor and mesenchymal type (2 cases). Follow-up data were available in 14 cases, in which 12 cases were sensitive to chemotherapy. Conclusions Pathologic type of hepatoblastoma rely mainly on the histology, which has a certain clinical prognostic significance. The stage of the tumor and the histopathologic type are two key prognostic factors in determining the survival of children with hepatoblastoma.
