Efficacy of bisphosphonates in reducing skeletal events in patients with multiple myeloma
10.3760/cma.j.issn.1009-9921.2012.07.004
- VernacularTitle:双膦酸盐类药物治疗骨髓瘤骨病的临床研究
- Author:
Sidan LI
;
Yan XU
;
Gang AN
;
Yafei WANG
;
Yaozhong ZHAO
;
Dehui ZOU
;
Lugui QIU
- Publication Type:Journal Article
- Keywords:
Multiple myeloma;
Bone diseases;
Diphosphonates;
Prognosis
- From:
Journal of Leukemia & Lymphoma
2012;21(7):397-400
- CountryChina
- Language:Chinese
-
Abstract:
Objective To review the efficacy of bisphosphonates in reducing skeletal events in patients with multiple myeloma. Methods Two hundred and five patients with newly diagnosed MM were enrolled in this retrospective study,with bisphosphonates or not.Skeletal-related events,therapeutic reaction of myeloma bone disease and patient survival were analyzed. Results The occurrence of skeletal-related events (SRE) per patient year (P＜0.01) and the time to first SRE (P＜0.05)were significantly lower in the reatment group than in the untreated group. After 6 cycles of treatment, a significant higher percentage of effective and marked effect patients were observed through X ray in the treatment group (80.0 ％) compared to the untreated group (48.7 ％), P＜0.001. There was no overall significant difference in the level of serum calcium between the two groups (P=0.278). After 6 cycles of treatment, the patients who received bisphosphonates had significant decreases in bone pain and lower ECOG score (ECOG≤2) compared to the untreated group (P＜0.05). Bisphosphonates were tolerated well, and the common adverse reaction including gastrointestinal reaction (3 cases,3.3 ％),fever (lcase,1.1％) and skin rash (2 cases,2.2 ％).There was no significant difference in overall survival between the two treatment groups,(P=0.580).Conclusion Infusions of Bisphosphonates could reduce the occurrence of skeletal- related events (SRE), prolong the time to first SRE and improve the quality of life of patients with multiple myeloma. Bisphosphonates could not prolong survival time of myeloma patients.
