Analysis of the clinical characteristics and prognostic factors of 19 primary nodal peripheral T-cell lymphoma

VernacularTitle:原发结内外周T细胞淋巴瘤19例临床特征及预后分析
Author: Li FU ; Mei XIONG ; Lingzhi YANG ; Zhao WANG
Publication Type:Journal Article
Keywords: Lymphoma,T-cell,peripheral; Prognostic factor
From: Journal of Leukemia & Lymphoma 2011;20(4):209-211
CountryChina
Language:Chinese
Abstract: Objective To investigate the clinical characteristics, therapeutic outcomes and prognostic factors of primary nodal peripheral T-cell lymphoma(PTCL). Methods Clinical records, therapy responses as well as prognostic factors of 19 PTCL patients were analyzed. Results The median age of the 19 patients was Ⅲ-Ⅳ, 84.2 % (16/19) with B symptoms, 84.2 % (16/19) with extranodal involvement, 57.9 % (11/19) with bone marrow involvement. After treatment, the complete remission (CR) rate was 36.8 % (7/19). The 2-year overall survival (OS) rate of all patients was 47.2 % and the 2-year progression free survival (PFS) rate was 25 %. The number of sites of extranodal involvement (EN)≥2, ECOG≥2, IPI＞2 and elevated β2-MG were poor prognostic factors. Conclusion Primary nodal PTCL is a heterogeneous group of aggressive T-cell lymphoma with poor chemotherapy results. Multifactors indicate negative prognosis.