The Plasma Levels of PAl-1, TGF-β and TNF-αin Pleural Effusion before and after Intrapleural Injection of Kanglaite Combined with Cisplatin
10.3969/j.issn.0253-9896.2009.07.004
- VernacularTitle:康莱特联合顺铂胸腔注人前后胸水PAI-1、TGF-β、TNF-α的测定
- Author:
Xuehong WEN
;
Hong ZHANG
;
Haiying LI
;
Yuechuan LI
;
Zengtao SUN
- Publication Type:Journal Article
- Keywords:
antineoplastic agents;
cisplatin;
hydrothorax;
plasminogen activator inhibitor 1;
transforming growth factor beta;
tumor necrosis factor-alpha
- From:
Tianjin Medical Journal
2009;37(7):538-540
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To detect the levels of plasminogen activator inhibitor-I (PAI-1), transforming growth factor-β (TGF-β)and tumor necrosis factor-α (TNF-α) in the pleural fluid before and after intrapleural injection of Kanglaite combined with Cisplatin, and the mechanisms thereof. Methods: Patients were randomly divided into three groups, the Kanglaite combined with Cisplatin group (combination treatment group), Kangkaite group and Cisplatin group. The levels of PAl-1, TGF-β and TNF-α were determined by ELISA in pleural effusion 24 h and 48 h before and after intrapleural injection of medicine. Results: The levels of PAI-1, TGF-βand TNF-αawere higher 24 h and 48 h after treatment compared with those of pre-treatment in three groups (P＜0.05). There were no statistical significances in levels of PAI-1 and TGF-β24 h after injection medicine in three groups. But the level of TNF-α was higher in the combination treatment group than that in Kangkaite and Cisplatin groups(P＜0.05). After injection medicine 48 h, the levels of PAl-I, GF-β and TNF-α were higher in the combination treatment group than those in Kangkaite group (P＜0.05). Conclusion: The treatment of Kanglaite combined with Cisplatin activates PAI-1, TGF-β and TNF-αcytokines and causes inflammatory, suppresses fibrinolytic activity. These cytokines promote fibrin and induce pleural adhesion.
