Advance in the pathogenesis and treatment of acute promyelocytic leukemia
10.3760/cma.j.issn.1009-9921.2009.10.020
- VernacularTitle:急性早幼粒细胞白血病的发病机制及治疗进展
- Author:
Qinfen XIE
;
Jie JIN
;
Jian HUANG
- Publication Type:Journal Article
- Keywords:
Leukemia;
PML-RARα;
Tretinoin;
Therapy
- From:
Journal of Leukemia & Lymphoma
2009;18(10):636-638
- CountryChina
- Language:Chinese
-
Abstract:
Pathogenesis of acute promyelocytic leukemia is one of the best understood disease among human hematological malignancies. Becasue of retinoic acid (RA) and arsenic trioxide which directly target the oncogenic promyelocytic leukemia-retinoic receptor A (PML-RARα) fusion protein, this disease became the first model for oncogene-targeted therapies.And other new therapy methods also gain great concern. The complexity of recent views of acute promyelocytic leukemia pathogenesis, as well as latest progress in clinical treatment were summarized and discussed in this review.
