The changes of Th17 and Th22 cells in patients with Helicobacter pylori infection
10.3969/j.issn.1673-4130.2014.21.017
- VernacularTitle:幽门螺杆菌感染患者外周血Th17与Th22细胞的改变
- Author:
Chunxiang YANG
;
Qingju ZHANG
;
Donglin JIANG
- Publication Type:Journal Article
- Keywords:
Helicobacter pylori;
Th17;
Th22;
IL-17;
IL-22
- From:
International Journal of Laboratory Medicine
2014;(21):2901-2902
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of Th17 and Th22 cells in patients with Helicobacter pylori(HP)infection . Methods 66 cases of HP infection (HP infection group) and 30 cases of healthy people (control group) were selected .The levels of Th17 and Th22 cells in peripheral blood were measured by flow cytometry and the level of IL-17 and IL-22 in serum were meas-ured by ELISA .Results Comparing with the control group ,the levels of Th17 ,Th22 ,IL-17 and IL-22 were significantly increased in HP infection group(P<0 .05) .The correlation analysis showed that the levels of Th17 ,Th22 ,IL-17 and IL-22 were significantly positive correlated with DPM(P<0 .01) .Conclusion Th17 and Th22 cells were actived in patients with HP infection ,which caused the high expression of immune effector molecules ,and promoted the progress of immune damage .
