Hpyerglycemic Effect of Arctiin in db/db Mice with Spontaneous Diabetes
- VernacularTitle:牛蒡子苷对自发型糖尿病db/db小鼠降血糖作用的实验研究
- Author:
Bo ZHANG
;
Bing WANG
;
Yongqiang WANG
;
Shuhua CAO
- Publication Type:Journal Article
- Keywords:
Arctiin;
db/db Mice;
Adiponection;
Blood glucose
- From:
China Pharmacist
2014;(11):1796-1799
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the hpyerglycemic action of arctiin in db/db mice with spontaneous diabetes and the underly-ing mechanism. Methods:Totally 40 db/db mice were randomly divided into five groups: the model control group, arctiin group re-spectively with the dose of 75, 150, 300 mg·kg-1 , 300 mg·kg-1 metformin group. The age-matched db/m mice were selected as the normal control group. The mice were administered with corresponding drugs or solvent by gavage for 4 weeks. The oral glucose tol-erance test was carried out at the end of the 3rd week. After the 4-week treatment, all the mice were fasted overnight (12h), and then the body weight and fasting blood glucose ( FBG ) were determined. The concentration of insulin ( INS ) , glycated serum protein ( GSP) , triglyceride ( TG) , total cholesterol ( TC) and adiponection ( APN) were detected. Results:Arctiin could significantly lower the body weight and FBG, improve the glucose tolerance, decrease the serum concentration of INS, GSP, TG, TC and APN(P<0. 05 or 0. 01). Conclusion:Arctiin has benefit effects against glucose/lipid metabolism disorder and insulin resistance in db/db diabetic mice. The mechanism may be related to up-regulating the expression of adiponection.
