Protective Effect of Yulangsan Polysaccharide on Liver Injury Induced by Cyclophosphamide in Mice
- VernacularTitle:玉郎伞多糖对环磷酰胺致小鼠肝损伤的保护作用
- Author:
Yuan LIANG
;
Tengyun LONG
;
Hongxia CHEN
;
Xinwen LIU
;
Renbin HUANG
;
Yang JIAO
- Publication Type:Journal Article
- Keywords:
Yulangsan polysaccharide;
Cyclophosphamide;
Liver injury
- From:
China Pharmacist
2014;(11):1800-1803
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the protective effect of Yulangsan polysaccharide ( YLSP) on liver injury induced by cyclophos-phamide(CTX) in mice. Methods:Liver injury induced by CTX in mice was used as the animal model and the mice were randomly di-vided into the normal group, CTX model group, biphenyldicarboxylate ( BPDC) group, YLSP group respectively with high, medium and low dose. Except the normal group, the other groups were injected with CTX, i. p. , for 7 days to make the model. Then the ani-mals in the YLSP groups were intragastrically administered with YLSP for 7 days. The activities of alanine aminotransferase( ALT) , as-partate aminotransferase( AST) in serum, malondialdehyde( MDA) , superoxide dismutase( SOD) , glutathione( GSH) and glutathione peroxidase ( GSH-Px) in liver tissue were investigated. Hematoxylin and eosin ( HE) stain was used to study the changes in hepatic tissue of the pathological mice. Results:Compared with the model group, YLSP could obviously reduce the activities of ALT, AST and the content of MDA, and increase the content of GSH, SOD and GSH-Px (P<0. 05 or P<0. 01). HE staining showed that YLSP had significant protective effect on liver injury induced by CTX. Conclusion:YLSP has protective effect on liver injury induced by CTX.
