Preparation and Quality Evaluation of Total Leaves Saponins of Panax Notoginseng Liposomal Gels
- VernacularTitle:三七叶总皂苷脂质体凝胶剂的研制与质量评价
- Author:
Chaoying LIU
;
Huihui ZHANG
;
Jiangqiao SUN
- Publication Type:Journal Article
- Keywords:
Total leaves saponins of panax notoginseng;
Liposomal gels;
Ginsenoside Rb3;
Quality
- From:
China Pharmacist
2014;(11):1817-1820
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the preparation of total leaves saponins of panax notoginseng liposomal gels and evaluate the quali-ty. Methods:The total leaves saponins of panax notoginseng liposomes were prepared by the film-dispersion method, and the formula was optimized by the orthogonal experimental design. A high-speed centrifugation method was applied to determine the encapsulation efficiency used as the evaluation index for the optimization of the preparation process. Then the gels were prepared and an HPLC meth-od was used to determine the content of ginsenoside Rb3 . The stability was preliminarily studied as well. Results:The preparation was semi-solid, and viscous gels with low skin irritation and good stability. The quality was accordance with the relevant provisions in Chi-nese Pharmacopoeia (2010 edition). Conclusion: The gels are with the properties of simple preparation process, reliable detection methods and stable and controllable quality.
