A multi-center study on effect of trichosanthin and methotrexate in treatment of uterine scar pregnancy
- VernacularTitle:天花粉蛋白与甲氨蝶呤治疗子宫瘢痕妊娠的疗效比较的多中心研究
- Author:
Ying SHI
;
Yumei LIAO
;
Runa WANG
;
Ying HONG
- Publication Type:Journal Article
- Keywords:
uterine scar pregnancy;
radix trichosanthis protein;
methotrexate;
multi-center study;
β-HCG;
progesterone;
adverse event
- From:
Chinese Journal of Biochemical Pharmaceutics
2014;37(7):93-95
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare effect of trichosanthin and methotrexate in the treatment of uterine scar pregnancy by a multi-center study. Methods 90 uterine scar pregnancy patients were selected from department of obstetrics and gynecology,in xinyang central hospital,the second affiliated hospital of zhengzhou university,zhumadian central hospital,using random number table divided into 2 groups.The control group of 45 cases were treated by methotrexate,gluteal muscle injection,50 mg one time,and took mifepristone 50 mg,two times a day,a week for a course of treatment;45 cases in the experimental group,were treated with trichosanthin,intramuscular injection of 1.2 mg/time,two times a day,and oral administration of bloven,0.6 g/d,a week for a course of treatment.The end of a course of treatment,2 groups of patients before and after treatment were compared of the serum progesterone level,β-HCG,side reactions after treatment.Results After treatment,progesterone levels were significantly reduced,and the experimental group levels were lower than the control group obviously,the difference has statistical significance(P<0.05).Serum -HCG level after the treatment significantly reduced,and the experimental group in serum -HCG levels were significantly lower,with statistical difference (P <0.05 ). Comparison of adverse reaction of the patients,the experimental group was obviously lower than control group,with statistically significant difference (P<0.05).Conclusion For the treatment of uterine scar pregnancy,trichosanthin and methotrexate have certain effect,but trichosanthin could lower serum progesterone,β-HCG levels more significantly than methotrexate,trichosanthin group side reaction rate is low.
