Diagnostic value of anti-mutated citrullinated vimentin antibodies for rheumatoid arthritis
10.3969/j.issn.1000-484X.2014.11.025
- VernacularTitle:抗突变型瓜氨酸波形蛋白抗体在类风湿关节炎中的诊断价值
- Author:
Wenlan ZHANG
;
Yongfu WANG
;
Li BAI
;
Fangrui YIN
;
Jianbo ZHAO
- Publication Type:Journal Article
- Keywords:
Anti-MCV;
Anti-CCP;
Rheumatoid factor;
Rheumatoid arthritis
- From:
Chinese Journal of Immunology
2014;(11):1546-1548
- CountryChina
- Language:Chinese
-
Abstract:
Objective: Combined detection of anti-mutated citrullinated vimentin ( anti-MCV ) antibodies, anti-cyclic citrullinated peptide ( anti-CCP) antibodies and rheumatoid factor ( RF-IgM) levels to investigate the diagnostic value of anti-mutated citrullinated vimentin (anti-MCV) antibodies for rheumatoid arthritis(RA).Methods: A total of 359 patients with RA,128 patients with other rheumatic diseases and 90 healthy controls were involved.Enzyme linked immunosorbent assay ( ELISA) was used to detect anti-MCV and anti-CCP, and dynamic immune nephelometry was applied to detect RF-IgM .The sensitivity and specificity were obtained from the experimental data.Results:The sensitivities of anti-MCV,anti-CCP and RF-IgM were 85.1%,76.7% and 82.7%in RA respectively.The specificities were 93.2%,95.1%and 80.1%respectively.Combined detection of anti-MCV and anti-CCP,the sensitivity decreased to 70.2%; but the specificity increased to 98.7%.The sensitivity reached to 89.5% with specificity 97.6%when the union of anti-MCV and anti-CCP positivity was used as criterion.Conclusion:Anti-MCV and anti-CCP are novel makers for RA diagnosis with high sensitivity and high specificity.Combination of anti-MCV and anti-CCP is more helpful for RA diagnosis.
