Study on Molecular Composition of Bismuth Potassium Citrate
- VernacularTitle:枸橼酸铋钾的分子组成研究
- Author:
Xiumei LI
;
Yuan YUAN
;
Liu YANG
;
Xinxin ZHAO
- Publication Type:Journal Article
- Keywords:
Bismuth potassium citrate;
Molecular composition;
Crystal forms
- From:
China Pharmacist
2014;(11):1821-1825
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the molecular composition of bismuth potassium citrate. Methods:The content of bismuth was de-termined using a volumetric method, the content of potassium was determined by atomic absorption spectrometry, and the content of cit-rate root was determined by ion chromatography. The structure was predicted using 1 HNMR and the crystal structure was studied using X-diffraction test and scanning electron microscopy. The changes in the percentage ratio of the three components were investigated by accelerated stability tests. Results:On the dried basis, the percentage of the three molecular components was bismuth of 35%-38%, potassium of 7%-11% and root citrate of 49%-52%. The NMR spectra and the data indicated that the product had three isomers with the molecular structure of bismuth∶potassium∶root citrate=2∶2∶2. The X-diffraction test and SEM showed that the three forms of amor-phous, monocrystalline and polycrystalline might exist. The percentage ratio of the three elements before and after the stability test was basically stable. Conclusion:Bismuth potassium citrate may have three crystal forms with the percentage of the three structure parts within a certain range, and the structure is relatively stable.
