Effect of Artificial Gastric Juice on Dissolution of Schizandrin A
- VernacularTitle:人工胃液对五味子甲素的溶出率考察
- Author:
Mingquan CHANG
;
Gaungyi YANG
;
Chen CHANG
;
Liangyong HUANG
- Publication Type:Journal Article
- Keywords:
Schisandra chinensis;
Artificial gastric juice;
Dissolution;
Schizandrin A
- From:
China Pharmacist
2014;(11):1837-1839
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the effect of artificial gastric juice on the dissolution of schizandrin A to provide the parameters for the best extraction method of Schisandra chinensis. Methods:Schisandra chinensis was respectively extracted by artificial gastric juice and water. Schizandrin A in the extracts was determined by HPLC, and the dissolution of schizandrin A in artificial gastric juice and water was studied and compared. Results:At 60 min, schizandrin A dissolution was 0. 483% in artificial gastric juice, and 0. 362%in water. Conclusion:The dissolution of schizandrin A in artificial gastric juice is 33. 4% higher than that in water, suggesting artifi-cial gastric juice can significantly improve the dissolution of schisandrin A.
