Drug Release Comparison of Nifedipine Sustained-release Tablets from Four Manufacturers
- VernacularTitle:四厂家硝苯地平缓释片（Ⅰ）在不同pH介质中释放度比较
- Author:
Yi WANG
;
Changjuan ZHAN
;
Wei XU
;
Hua WANG
;
Yong ZHANG
- Publication Type:Journal Article
- Keywords:
Nifedipine sustained-release tablets;
Release rate;
UV spectroscopy
- From:
China Pharmacist
2014;(11):1856-1858
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the drug release of nifedipine sustained-release tablets from four manufacturers to evaluate the intrinsic quality. Methods:The drug release rate was determined by UV respectively with pH 1. 2 HCl solution, pH 4. 0 sodium ace-tate buffer, pH 6. 8 phosphate buffer and water as the dissolution medium. The dissolution curves were compared by f2 factor. Results:The drug release rate of nifedipine sustained-release tablets from the four manufacturers all met quality standard of our country, al-though the dissolution curves in the different dissolution medium was various. Conclusion:There are differences in intrinsic quality a-mong the nifedipine sustained-release tablets from the four manufacturers. The dissolution examination standard should be improved fur-ther.
