Optimization of Compatibility Plan for Sodium Nitroprusside and Infusions by Orthogonal Design
- VernacularTitle:正交试验法优选注射用硝普钠与输液配伍方案
- Author:
Xiaoming LIN
;
Baohan WEI
;
Yi ZENG
;
Pingyuan WEI
;
Hanqin LIANG
;
Weiqian XIE
;
Mingzhong CHEN
- Publication Type:Journal Article
- Keywords:
Sodium nitroprusside;
HPLC;
Compatibility;
Orthogonal design
- From:
China Pharmacist
2014;(11):1960-1962
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the best compatibility plan for nitroprusside sodium for injection. Methods: An L16 (43 × 26 ) orthogonal design was used with four factors:temperature, solvent, solvent volume and time. The content of sodium nitroprusside was detected by HPLC, the insoluble particles were observed by a GWF-5J type particle analyzer, pH was detected by a PHS-2C preci-sion acidity meter, and a comprehensive scoring method was used to optimize the compatibility plan. Results:The optimized compati-bility plan was as follows:50mg sodium nitroprusside was dissolved in 250ml sodium chloride injections, avoiding light and used up in 26h. Conclusion:The plan provides scientific basis for the clinical medication.
