New advances in lymphoma pathology
10.3969/j.issn.1007-3969.2014.10.001
- VernacularTitle:淋巴瘤病理研究新进展
- Author:
Xiaoqiu LI
- Publication Type:Journal Article
- Keywords:
Advances;
Lymphoma;
B-cell;
T and NK-cell;
Classification;
Aggressive;
Indolent clonal lymphoproliferative disorders
- From:China Oncology
2014;(10):721-726
- CountryChina
- Language:Chinese
-
Abstract:
Updated knowledge about lymphoma pathology has been accumulated ever since the publication of the current WHO classiifcation of lymphomas in 2008. For B-cell non-Hodgkin lymphomas, endeavors have been made for approaching a better classiifcation of those highly aggressive and heterogeneous subtypes (e.g., diffuse large B-cell lymphomas) on the molecular biological basis. In addition, there is a growing interest in understanding and deal-ing with the borders of overt malignant lymphomas and certain clonal lymphproliferative disorders that are not overtly malignant. On the other hand, recent advances in understanding the subsets of T and NK (T/NK)-cell lineage and their differentiation, as well as the genetic aberrations or dysregulated signaling pathways in their neoplastic counterparts, have provided us novel insights into the biology of peripheral T/NK-cell lymphomas. Indolent clonal T/NK-cell prolif-erations, especially those arising from the mucocutaneous sites, have also received increased attention. These advances may contribute to the evolution of the classiifcation of lymphomas.
