Impact study of curcumin on ASO and IL-8 level changes in serum of psoriatic mice model induced by TPA
- VernacularTitle:姜黄素对TPA诱导的银屑病小鼠模型血清ASO和IL-8水平的影响研究
- Author:
Ying SUN
- Publication Type:Journal Article
- Keywords:
curcumin;
TPA induce;
psoriatic mouse model;
ASO;
IL-8
- From:
Chinese Journal of Biochemical Pharmaceutics
2014;37(7):46-48
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the impact of curcumin on antistreptolysin“O”(ASO)and interleukin 8 (IL-8)level changes in serum of psoriatic mice model induced by phorbol ester(TPA).Methods 132 SCID mice were selected and divided into three groups.43 mice in normal group, 46 mice in model group,and 43 mice in intervention group.The mice of model group and intervention group were set up psoriasis model induced by TPA. Mice of the three groups were bred in the same environment,curcumin was injected in the intervention group mice,0.02 g/100 g,once a day,two weeks for a period of treatment.ASO and IL-8 level were compared amorg the three groups of mice after treatment.Results Before the treatment,compared with the normal group,positive rate of ASO in model group and intervention group increased significantly,and the difference was statistically significant (P<0.05 );after treatment,the level of intervention group was significantly lower than model group,and the difference was statistically significant (P<0.05 );before the treatment,compared with the normal group,IL-8 level in intervention group and model group increased significantly,and the difference was statistically significant (P<0.05 );after treatment,level of the intervention group was significantly lower than model group,and the difference was statistically significant (P<0.05).Conclusion Curcumin could effectively reduce ASO and IL-8 level in serum of psoriatic mice model, improve the clinical symptoms of psoriasis mice,it is an effective drug for treatment of psoriasis.
