Application of high-throughput sequencing on gut microbiota for the diagnosis of colorectal cancer
- VernacularTitle:高通量测序技术用于肠道菌群结构与大肠癌发生关系的研究
- Author:
Lei HE
;
Min LI
- Publication Type:Journal Article
- Keywords:
Colorectal neoplasms;
Gastrointestinal tract;
Microbiota;
High-throughput nucleotide sequencing
- From:
Chinese Journal of Laboratory Medicine
2014;(10):736-738
- CountryChina
- Language:Chinese
-
Abstract:
Human colorectal cancer ( CRC ) presents a considerable disease burden worldwide.Besides the genetic factor, gut microbiota could be another important factor resulting in CRC and has become a hot research topic.Along with the increasing accessibility of high-throughput sequencing, the role of structure of microbiota and potential pathogens in colorectal carcinogenesis have become more and more clear.In this review, the recent insights into contributions of the microbiota and candidate CRC-potentiating species to CRC were discussed.Moreover, new findings on the role of candidate pathogens in cancer causation were highlighted.Two pathogenic models were introduced in this review.High-throughput sequencing of gut microbiota will assist us in understanding the pathogenesis of CRC, providing a theoretical basis for disease surveillance.
