Effect of tea polyphenols on oxidative stress and micro inflammatory condition in maintenance hemodialysis patients
- VernacularTitle:茶多酚对维持性血液透析患者氧化应激及微炎症状态的影响
- Author:
Xueyi LIU
;
Hong CHAI
;
Zhancai DU
;
Jing ZHANG
;
Li YUAN
- Publication Type:Journal Article
- Keywords:
hemodialysis;
tea polyphenol;
micro inflammation;
oxidative stress;
nuclear factor-κB
- From:
Chinese Journal of Biochemical Pharmaceutics
2014;37(7):87-89
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influence and the possible mechanism of tea polyphenols on maintenance hemodialysis (MHD)patients’ oxidative stress and micro inflammatory condition.Methods 60 cases of MHD patients were randomly divided into routine group and tea polyphenols group.30 healthy subjects were chosen as normal control group.After 3 months,MDA,AOPP,SOD,TNF-α,CRP,IL-6 and NF-κB of routine group and tea polyphenols group were detected.Results Before treatment,compared with normal control group,MDA and AOPP of routine group and tea polyphenols group increased (P <0.01 ),SOD decreased (P <0.01 );after treatment,compared with routine group,MDA and AOPP of tea polyphenols group decreased (P<0.01),SOD increased (P<0.01).After treatment,compared with normal control group,NF-κB,TNF-α,CRP, IL-6 and oxidative index of routine group and tea polyphenols group increased,and the difference was statistically significant (P<0.01);compared with routine group,oxidative index of tea polyphenols group decreased,and the difference was statistically significant (P <0.01 ).Conclusion Tea polyphenol can improve MHD patients’oxidative stress and micro inflammatory state.
