Effect of tranexamic acid on blood loss in vein and joint of patients with total knee arthroplasty
- VernacularTitle:氨甲环酸对膝关节置换术患者静脉与关节内失血的影响研究
- Author:
Lian TANG
- Publication Type:Journal Article
- Keywords:
tranexamic acid;
total knee arthroplasty;
hemoglobin;
blood loss
- From:
Chinese Journal of Biochemical Pharmaceutics
2014;37(7):105-107
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of tranexamic acid on the blood loss in vein and joint of patients with total knee arthroplasty. Methods 90 patients diagnosed with primary osteoarthritis from January 2012 to December 2013 were selected as subject.They were scheduled for the first-time unilateral total knee arthroplasty.All patients were divided into three groups randomly.Experimental group one was tranexamic acid intravenously,Experiment group two was given tranexamic acid with knee local injection,and Experimental group three was given nothing.Hemoglobin and total blood loss were detected and compared in 48 hours after operation in three groups;subcutaneous ecchymosis situation within 7 days were recorded and compared.Results Hemoglobin levels of Experiment group one and Experiment group two in 20 hours and 48 hours after operation were more than those of Experiment group three significantly (P<0.05 );hemoglobin levels in three groups in 20 hours and 48 hours after operation were all less than before operation (P<0.05 ),and hemoglobin in 20 hours after operation were all less than those of 48 hours.Total blood loss,blood transfusion cases and subcutaneous ecchymosis in Experiment group one and Experiment group two were all less than those in Experiment group three (P<0.05 ), but there was no statistically significant difference of those datas between Experiment group one and Experiment group two.Conclusion Tranexamic acid could reduce blood loss in knee replacement surgery and reduce the suffering and economic burden of patients.
