Advances in research on oximes as antagonists of nerve agent
10.7644/j.issn.1674-9960.2014.10.023
- VernacularTitle:重活化剂抗神经性毒剂中毒作用研究进展
- Author:
Feng CHENG
;
Zhiyong NIE
;
Yongan WANG
- Publication Type:Journal Article
- Keywords:
nerve agents;
reactivator;
treatment effect;
kinetics
- From:Military Medical Sciences
2014;(10):837-841
- CountryChina
- Language:Chinese
-
Abstract:
Nerve agents (NAs) belong to the class of organic phosphorus compounds which are acetylcholinesterase ( AChE) inhibitors, including soman, sarin, tabun,VX, etc.NAs are extremely toxic and considered as the most danger-ous chemical warfare agents.The current standard treatment for poisoning by nerve agents consists of the combined adminis-tration of anticholinergic drugs such as atropine sulphate, AChE reactivators such as pralidoxime, obidoxime and HI-6 and diazepam for anticonvulsant effects, but oximes are therapeutic antidotes against nerve agent intoxications which exert the therapeutic purposes primarily by reactivating the NAs-inhibited AChE.In this paper, the mechanism of nerve agents, the main working procedure of anti-NAs drugs, the chemical structure of classic reactivator, the corresponding antitoxic action, in vivo and in vitro effects and metabolic kinetics are reviewed.
