Meta analysis of efficacy and safety of levofloxacin in treatment of refractory pulmonary tuberculosis hemoptysis
- VernacularTitle:左氧氟沙星治疗难治性肺结核咯血的有效性和安全性meta分析
- Author:
Zhongting FEI
;
Zhen CHEN
;
Yao TANG
- Publication Type:Journal Article
- Keywords:
levofloxacin;
tuberculosis;
haemoptysis;
effectiveness;
security
- From:
Chinese Journal of Biochemical Pharmaceutics
2014;37(7):164-166
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study efficacy and safety of the levofloxacin in treatment of refractory pulmonary tuberculosis hemoptysis by meta analysis.Methods Pubmed (2000/2014-07),EMbase (2000/2014-07),the Cochrane library (2014,7),the Chinese biomedical literature database (2000/2014-07)were retrieved about the randomized controlled trials of levofloxacin in treatment of refractory pulmonary tuberculosis hemoptysis,and the time was limited from January 2000 to July 2014.After objective evaluation of the retrieved paper quality,Cochrane collaboration with Rev Man 5. 3 software system was applicated to Meta analysis.Results In six reports of the sputum negative rate,levofloxacin group was significantly higher,and the difference was statistically significant (OR=4.21,95%CI:3.08 ~5.75,P<0.0001);adverse reactions in three articles,the difference of adverse reactions incidence had no statistical significance (OR =0.82,95%CI:0.56 ~1.18,P =0.28)between experimental group and control group, respectively.Conclusion The clinical effect of levofloxacin in treatment of refractory pulmonary tuberculosis hemoptysis is significant with a high security, which gives a guidance for clinical treatment and is worth clinical promotion.
