Study on hydroxysafflor yellow A enteric pellets
- VernacularTitle:羟基红花黄色素A肠溶微丸的研究
- Author:
Yu ZOU
;
Zhiyong LI
;
Li ZHOU
;
Kun ZHAO
;
Hong PAN
;
Yingcai NIU
- Publication Type:Journal Article
- Keywords:
hydroxysafflor yellow A;
enteric pellets;
in vitro release;
in vivo pharmacokinetics
- From:
Chinese Journal of Biochemical Pharmaceutics
2014;37(7):180-183
- CountryChina
- Language:Chinese
-
Abstract:
Objective To prepare the hydroxysafflor yellow A (HSY-A)enteric coating pellets,and investigate in vitro release and in vivo pharmacokinetic characteristics.Methods HSY-A enteric coating pellets were prepared by extrude-rounding and fluid bed technique.The micromeritic characteristics,the factors affecting the release properties of enteric coating pellets the release mechanism were explored,and the in vivo pharmacokinetic behaviors were also evaluated.Results The in vitro release behavior of HSY-A from enteric coating pellets could be described by Ritger-peppas equation,and fit diffusion mechanism,in vivo pharmacokinetic test confirmed the argument that pellets have good acid residence and enteric properties. Conclusion HSY-A enteric coating pellets have been successfully prepared and the expected release properties is achieved in the study.
