Meta-analysis and associated mechanism on prognostic role of miR-31 in carcinomas
10.3969/j.issn.1673-4130.2014.20.004
- VernacularTitle:miR-31在肿瘤中预后作用的 meta 分析及机制
- Author:
Wenbo FU
;
Yaqin SONG
;
Lan YANG
;
Jianbo ZHU
;
Yutao WEI
- Publication Type:Journal Article
- Keywords:
carcinoma;
miR-31;
prognosis;
tumor markers;
meta analysis
- From:
International Journal of Laboratory Medicine
2014;(20):2729-2731
- CountryChina
- Language:Chinese
-
Abstract:
Objective To synthetically evaluate the relationship between miR-31 and the prognosis of carcinoma and to investi-gate its related mechanism.Methods The correlative literatures of tumor prognosis were retrieved from the electronic databases PubMed,EMBASE and ISI Web of Science.The pooled hazard ratios (HRs)and 95% confidence interval(95%CI )were extracted. The prognostic data were performed the synthesis analysis.Results A total of 7 trials conformed to the inclusion criteria including accumulated 2 012 cases of carcinoma.Meta-analysis revealed that the decrease of miR-31 expression in the tumor patients had the poor prognosis (HR=0.784,95%CI :0.630-0.974);in the subgroup analysis,the synthesis results adopting the multivariable a-nalysis and China subjects were 3.512 (95%CI :1.797-6.865)and 1.574 (95%CI :1.062-2.333),which indicating that the in-crease of miR-31 expression predicted the poor prognosis;miR-31 had no statistical significance in the digestive system (P >0.05). Conclusion The prognostic role of miR-31 may possess the histological and regional specificity and has the potential as a novel marker.
