Expression change of serum HCY,UⅡ,ACE and NT-proBNP in essential hypertension patients
10.3969/j.issn.1673-4130.2014.20.009
- VernacularTitle:原发性高血压患者血清 HCY、UⅡ、ACE 及 NT-proBNP 的表达变化
- Author:
Bin CHEN
;
Yongzhi XU
;
Yanhong CHEN
;
Chunzheng LIN
;
Jiali FENG
- Publication Type:Journal Article
- Keywords:
homocysteine;
angiotensin converting enzyme;
N-terminal pro-brain natriuretic peptide;
urotensinⅡ;
ele-mentary hypertension
- From:
International Journal of Laboratory Medicine
2014;(20):2741-2743
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between essential hypertension(EH)with serum homocysteine(HCY),uroten-sinⅡ(UⅡ),angiotensin converting enzyme(ACE)and N-terminal pro-brain natriuretic peptide(NT-proBNP).Methods By collec-ting the clinical cases,UⅡwas determined by ELISA and HCY,ACE and NT-proBNP were simultaneously detected by ELISA.The detection results were analyzed and compared between the patients with essential hypertension(EH group)and the healthy con-trols.Results The levels of serum HCY,UⅡ,ACE and NT-proBNP in the EH group were significantly increased compared with the healthy control group;the area under curve (AUC)of serum HCY,UⅡ,ACE and NT-proBNP in the ROC curve in the EH group were 0.93,0.765,0.792 and 0.972 respectively,which showed clinical diagnostic significance.Conclusion The levels of HCY,UⅡ,ACE and NT-proBNP are highly expressed in EH and have significant differences compared with the healthy popula-tion,which has the diagnostic value to EH.
