Diagnostic value of combined detection of six kinds of tumor markers on lung cancer
10.3969/j.issn.1673-4130.2014.20.011
- VernacularTitle:6种肿瘤标志物联合检查对肺癌的诊断价值
- Author:
Wangjiao HE
;
Liuqing FAN
- Publication Type:Journal Article
- Keywords:
tumor marker;
lung cancer;
diagnostic value
- From:
International Journal of Laboratory Medicine
2014;(20):2746-2748
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the value of serum tumor markers neuron specific enolase (NSE),cytokeratin 19 fragment (CYFRA21-1),carcinoembryonic antigen (CEA),carbohydrate antigen 125 (CA125 ),carbohydrate antigen 153 (CA153)and fer-ritin in diagnosing lung cancer.Methods The serum levels of NSE,CYFRA21-1,CEA,CA125,CA153 and ferritin were detected by the electrochemiluminescence method in 151 cases of lung cancer(lung cancer group),100 cases of benign lung disease (benign dis-ease group)and 50 cases of healthy control group.The detection results were analyzed.Results The serum levels of NSE,CY-FRA21-1,CEA,CA125,CA153 and ferritin in the lung cancer group were significantly higher than those in the benign lung disease group and the healthy control group with statistical differences (P <0.05);the NSE level in small cell lung cancer was higher than that in squamous carcinoma and adenocarcinoma with statistical difference(P <0.05).The CYFRA21-1level in squamous carcinoma and adencarcinoma was higher than that in small cell lung cancer with statistical difference (P <0.05).The sensitivity of NSE was highest in six tumor markers,which was 82.8%.In 6 tumor markers,3 markers were positive,the positive rate of lung cancer was higher,while the false positive rate was significantly reduced.Conclusion The levels and positive rates of serum tumor markers are associated with the pathological type of lung cancer.The combined detection of serum tumor markers can increase the sensitivity and accuracy in early diagnosis of lung cancer.The combination measurement of CEA,NSE and CYFRA21-1 is the first choice.
