Analysis of lymphocyte subsets and activated T lymphocyte in patients with common malignant tumors
10.3969/j.issn.1673-4130.2014.20.016
- VernacularTitle:常见恶性肿瘤患者机体淋巴细胞亚群和活化T淋巴细胞的分析
- Author:
Aijun SHI
;
Xiaoliu WU
;
Zongli SHEN
;
Liling DAI
- Publication Type:Journal Article
- Keywords:
malignant tumor;
lymphocyte subsets;
activated T lymphocyte;
flow cytometry
- From:
International Journal of Laboratory Medicine
2014;(20):2758-2759
- CountryChina
- Language:Chinese
-
Abstract:
Objective To comparatively study the difference status of lymphocyte subsets and activated T lymphocyte between preoperation and intraoperation,and to investigate the influence of operation on lymphocyte subsets and their activation in the pa-tients with malignant tumors.Methods The lymphocyte subsets and their activated cells were determined in 42 cases of common malignant tumors by the flow cytometry.Results The levels of CD3 + ,CD4 + ,CD8 + cells during intraoperation were obviously de-creased compared with preoperation,the difference in CD3 + and CD4 + had statistical significance(P <0.05),while the difference of CD8 + had no statistical significance(P >0.05).NK,CD19 + ,CD3 + HLA-DR+ were significantly increased,the difference of NK and CD19+ had no statistical significance(P >0.05),while the difference with CD3 + HLA-DR+ had statistical significance(P <0.05). Conclusion The cellular immune function in the patients with malignant tumor is in inhibitory status.Operation makes the cellular immune function to be further injured.The stress responses of operation and trauma increase the expression of NK,CD19 and acti-vated T lymphocytes.It is suggested that the patients with malignant tumor should use the immune response modifier before opera-tion to enhance the cellular immune function for ensuring the effect of postoperative radiochemotherapy sequential treatment.
