In vitro antibacterial activity of tigecycline against carbapenems-resistant Acinetobacter calcoacetcus-Acinetobacter baumannii complex
10.3969/j.issn.1673-4130.2014.20.022
- VernacularTitle:替加环素对碳青霉烯类耐药鲍曼醋酸钙复合不动杆菌的体外抗菌活性
- Author:
Daohong ZHOU
;
Yun PENG
;
Xinyong CAI
;
Yipeng LIU
;
Min LI
;
Yi WANG
;
Weiping LU
- Publication Type:Journal Article
- Keywords:
tigecycline;
carbapenems;
Acinetobacter calcoacetcus-Acinetobacter baumannii complex;
in-vitro antibacterial activity
- From:
International Journal of Laboratory Medicine
2014;(20):2771-2772
- CountryChina
- Language:Chinese
-
Abstract:
Objective To measure the in vitro antibacterial activity of tigecycline against carbapenems-resistant Acinetobacter calcoacetcus-Acinetobacter baumannii complex.Methods The isolated strains of carbapenems-resistant Acinetobacter calcoacetcus-Acinetobacter baumannii complex were collected in our hospital from December 2013 to February 2014.The MIC test strip was a-dopted to measure the MIC value of tigecycline.The break point adopted the judgment criteria published by FDA.Results All 61 strains of carbapenems-resistant Acinetobacter calcoacetcus-Acinetobacter baumannii complex had extremely high drug resistant rate to the commonly used antimicrobial agents.The sensitive rate of tigecycline was 80.3%,intermediation was 19.7% and no re-sistant strain was found in this study.MIC50 and MIC90 were 2 μg/mL and 3 μg/mL respectively.Conclusion Tigecycline has bet-ter in vitro antibacterial activity to the carbapenems-resistant Acinetobacter calcoacetcus-Acinetobacter baumannii complex isolated in our hospital.
