Change of expression of TC-1,CyclinD1 andβ-catenin in non-small cell lung cancer and its meaning
10.3969/j.issn.1673-4130.2014.20.002
- VernacularTitle:非小细胞肺癌组织中 TC-1、CyclinD1、β-catenin 蛋白表达的变化及意义
- Author:
Jiankui LUO
;
Shiyun XING
- Publication Type:Journal Article
- Keywords:
non-small cell lung cancer;
thyroid cancer related gene-1;
CyclinD1;
β-catenin
- From:
International Journal of Laboratory Medicine
2014;(20):2723-2725
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression situation of thyroid cancer related gene-1 (TC-1),CyclinD1 andβ-catenin in the tissues of non-small cell lung cancer(NSCLC)and their relationship with the clinical pathologic characteristics,to analyze their relationship with the regulation of Wnt/β-catenin signal pathway to provide the basis for studying the role of TC-1 in NSCLC. Methods The expressions of TC-1,CyclinD1 and β-catenin in 48 patients with NSCLC were detected by immunohistochemical SP method and analyzed by combining the clinical pathological features.Results The expression levels of TC-1,CyclinD1 andβ-catenin in the NSCLC tissue were significantly higher than those in the normal lung tissue;in which,the expression of TC-1 in NSCLC tis-sue was associated with lymph node metastasis and TNM stages;the expression ofβ-catenin in NSCLC tissue was related with the pathological types and tissue differentiation degree.Conclusion The expressions of TC-1,CyclinD1 andβ-catenin show the up-regu-lating trend in NSCLC and may play an important role in the development of lung cancer;TC-1 may be involved in the regulation of Wnt/β-catenin signaling pathway,which provide the new research thought of the NSCLC targeted therapy.
